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KMID : 0927720100110040324
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Korean Clinical Diabetes
2010 Volume.11 No. 4 p.324 ~ p.332
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Glucose Control of the Patients with Type 2 Diabetes Using a Long Acting Insulin and Insulin Secretagogue According to Fasting and Postprandial C-peptide
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Lee Seo-Hee
Park So-Young
Kim Min-Kang
Kim Eun-Ji
Kang Jun-Goo
Ryu Ohk-Hyun
Kim Chul-Sik
Lee Seong-Jin
Hong Eun-Gyoung
Kim Doo-Man
Yoo Jae-Myung
Ihm Sung-Hee
Choi Moon-Gi
Yoo Hyung-Joon
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Abstract
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Background: It has been noted that Korean type 2 diabetic patients have lower insulin secretory function than do diabetic patients of European descent. We conducted the present study to evaluate the relationshipbetween glucose control and the difference between fasting and postprandial c-peptide in Korean type 2diabetic patients.
Methods: We evaluated fasting blood glucose level, fasting C-peptide level, A1C, lipid profiles, postprandial 2 hour blood glucose level, and postprandial 2 hour C-peptide level in 60 Korean type 2 diabetic patients (38 male, 22 female, age 51.9 ± 11.5 years old , duration of diabetes 9.6 ± 6.9 years, BMI 24.5 ± 2.9 kg/m2). We used fasting C-peptide, postprandial 2-hour C-peptide, and Δ C-peptide level to assess insulin secretory function and beta cell responsiveness. We divided patients into 3 groups according to Δ C-peptide level. The patients were treated using long acting insulin and insulin secretagogue (sulfonylurea, meglitinide). Three months later, we reevaluated fasting blood glucose, postprandial 2-hour glucose, and A1C according to ΔC-peptide level.
Results: We observed decreases in Δ C-peptide according to duration of diabetes. However, there were no
significant dfferences in the fasting blood glucose, post prandial 2 hour blood glucose, or A1C according to postprandial 2-hour C-peptide or Δ C-peptide.
Conclusions: We did not observe significant improvements of blood glucose status according to the difference between fasting and postprandial C-peptide.
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KEYWORD
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A1C, β-cell, C-peptide, Diabetes, Long acting insulin, Meglitinide, Sulfonylurea
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